Human Health, Radiological and Ecological Risk Assessment
ISSi is a leader in environmental and human health risk assessment and in the related fields of toxicology, exposure modeling, and fate and transport modeling. ISSi has provided scientific, technical, and regulatory support in assessing risks to human health from chemicals in air, water, soil, and food. With a team of chemists and toxicologists, environmental scientists, biologists, engineers, health specialists, statisticians, survey designers, and epidemiologists, we have the multidisciplinary expertise to design and conduct national-level and site-specific risk assessments.
ISSi offers a unique combination of risk assessors and other professionals with expertise in all 4 components of the health risk paradigm:
Hazard Identification--Identifying the nature and magnitude of potential hazards and designing
strategies to evaluate human health risks.
Dose Response--Studying the relationships between an individual's exposure to toxic substances,
the amount of chemical or chemical metabolites retained in the body (internal dose or body burden), and health outcomes.
Human Exposure Modeling--Modeling and predicting aggregate and cumulative exposures of
humans to chemicals.
Risk Characterization--Describing and categorizing the uncertainty and variability in risk estimates
to support decision making and policy analysis.
We offer a full range of services for any client requiring human health risk assessments, including:
Identifying pollution sources.
Predicting contaminant fate and transport.
Quantifying chemical exposures.
Performing statistical analyses on complex data sets.
Evaluating toxicological data.
Conducting epidemiological studies of health outcomes.
ISSi also has experience applying and developing human health benchmarks to evaluate potential health effects caused by environmental exposure to chemicals. We routinely develop solutions to complex risk analyses through innovative approaches that allow the client to make decisions or investigate questions throughout each phase.
ISSi also has substantial experience in conducting and reviewing diverse ecological risk assessments. We develop ecological benchmarks and screening levels for different classes of chemicals and characterize the stress and risk to plants and animals caused by various chemicals. ISSi supports the development of comprehensive ecological risk models and databases by
Characterizing representative terrestrial and aquatic habitats that reflect the variability across a
broad range of ecosystems.
Identifying ecological receptors, such as birds and amphibians, that make up the food web in
those representative habitats.
Applying simulation models that track chemical movement through aquatic and terrestrial food
webs.
Designing ecological exposure models that account for spatial variability in chemical exposure.
Developing databases on wildlife toxicity, physical and behavioral attributes of wildlife, and habitat
